Dihydrotestosterone (DHT) binds to the androgen receptor (AR) and changes its shape to make it more stable and efficient. When DHT binds to the receptor, two events then occur: the receptor becomes more flexible and able to bind androgens (like a “molten glob”, as described in the abstract) so the domain sites are more capable of interactions, between each, then it compacts into a more stable and dense form. This process enhances the receptor’s ability to recruit helpers (coactivators) for muscle-building and other androgen-driven genomic and non-genomic transcription. Simply put, DHT supercharges the AR by making it stronger and better at doing its job.